a Farnesol → 3,7,11-Trimethyl-1-dodecanol

Participants

Reaction Steps

A flask containing a stirring suspension of farnesol (5.7 ml, 22.5 mmol) and palladium on carbon (10% Pd, 1 g, 0.04 equ) in ethanol (15 ml) was evacuated, and then filled with hydrogen. The reaction mixture was then stirred under an atmosphere of hydrogen for 36 hours. After this time the reaction was filtered and the filtrate concentrated in vacuo to give hexahydrofarnesol (44) (4.81 g, 93%) as a colourless oil.

Provenance & Evidence