反应详情

To a stirring suspension of N-(4-methoxy-phenyl)-acetamide (5.253 g, 32 mmol) and acetyl chloride (6.6 ml, 93 mmol, 2.9 equ) in dichloromethane (55 ml) was added aluminium trichloride (14.55 g, 109 mmol, 3.4 equ) in portions over 90 minutes. The reaction was then heated to reflux for 4.5 hours and cooled overnight. The mixture was poured onto ice then extracted into dichloromethane (5×), dried (MgSO4) and concentrated in vacuo to give N-(3-acetyl-4-hydroxy-phenyl)-acetamide (5.336 g, 87%) as a pale green solid.

1. temperatureThe reaction was then heated
2. temperatureto reflux for 4.5 hours
3. temperaturecooled overnight
4. additionThe mixture was poured onto ice
5. extractionthen extracted into dichloromethane (5×)
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo