HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → N-[4-(Aminomethyl)-2-chloro-6-methylphenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 4-(Aminomethyl)-2-chloro-6-methylaniline | HCID 55255766 | — |
| Reactant | N-(2-Chloro-4-cyano-6-methylphenyl)acetamide | HCID 58962910 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(Aminomethyl)-2-chloro-6-methylphenyl]acetamide | HCID 58962953 | — |
Reaction Steps
Step G (2): 4-acetamido-3-chloro-5-methylbenzonitrile was reduced to 4-amino-3-chloro-5-methylbenzylamine by heating it at reflux with 2.2 eq. of LAH in THF for 2 hrs. 1H NMR (500 MHz, CD3OD) δ 7.31 (s, 1 H), 7.17 (s, 1 H), 3.73 (s, 2 H), 2.23 (s, 3 H), 2.15 (s, 3 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601751B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-ad164ec96c0144ac93b09712038a603f |
| Source note | uspto-grants-2009_10 |