Dichlorobenzylamine → HCID 178488079, compound

HRID 1819691Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=3)[NH:16][CH:15]=2)[CH:5]=[C:4]([Cl:27])[C:3]=1NC(=O)C.ClN(Cl)CC1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([Cl:27])[CH:3]=1)[CH2:8][NH:9][C:10]([NH:11][C:12](=[O:25])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([O:23][CH3:24])[CH:21]=2)[NH:16][CH:15]=1)=[NH:26]

Participants

Reactant 2

HCID 12720694Dichlorobenzylamine

HCID 178488081HCID 178488081, compound

Product 1

HCID 178488079HCID 178488079, compound

Procedure

In a manner similar to that used in the preparation of the compound of example 2, but using dichlorobenzyl amine in step 3 (B), the title compound was prepared. MS (ESI) (M+H)+=405.28. 1H-NMR (500 MHz, CDCl3) δ 8.25 (d, 1H), 7.64 (s, 1 H), 7.53 (s, 1 H), 7.09 (s, 1 H), 6.88 (s, 2 H), 6.84 (bs, 4 H), 6.62 (d, 1 H), 4.37 (s, 2 H), 4.13 (s, 2 H), 3.89 (s, 3 H).

Sources & evidence

ORD record: ord-19cb5375cd9b4a5bae36c10997aaddce
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601751B2

Reaction notes

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