5-Fluoroindole-3-acetic acid → HCID 178512109, Verbindung

HRID 1819692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1819692
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][C:10]([NH2:26])=[N:11][C:12](=[O:25])[CH2:13][C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20](OC)[CH:21]=3)[NH:16][CH:15]=2)[CH:5]=[C:4]([Cl:27])[C:3]=1NC(=O)C.[F:32]C1C=C2C(=CC=1)NC=C2CC(O)=O.ClN(Cl)CC1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([Cl:27])[CH:3]=1)[CH2:8][NH:9][C:10]([NH:11][C:12](=[O:25])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([F:32])[CH:21]=2)[NH:16][CH:15]=1)=[NH:26]

Komponenten

4

Edukt 3

HCID 967505-Fluoroindole-3-acetic acidHCID 12720694DichlorobenzylamineHCID 178488081HCID 178488081, Verbindung

Produkt 1

HCID 178512109HCID 178512109, Verbindung

Versuchsvorschrift

In a manner similar to that used in the preparation of the compound of example 2, but using 2-(5-fluoro-1H-indol-3-yl)acetic acid in step 4 (A) and dichlorobenzyl amine in step 4 (B), the title compound was prepared. MS (ESI) (M+H)+=393.24. 1H-NMR (500 MHz, CDCl3) δ 7.53 (s, 1 H), 7.08 (d, 1 H), 6.87 (bs, 3 H), 6.84 (bs, 4 H), 6.42 (m, 1 H), 4.38 (s, 2 H), 4.12 (s, 2 H).

Quellen und Nachweise

ORD-Eintrag
ord-beedaecf413549c79fbcf3d21a841a41
Quelldatensatz
uspto-grants-2009_10
Patentnummer
US07601751B2

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