5-Bromo-3-indoleacetic acid → N-[2-(5-Bromo-1H-indol-3-yl)-acetyl]-N'-[3-chloro-4-(4-methyl-piperazin-1-yl)-benzyl]-guanidine

Participants

Reaction Steps

In a manner similar to that used in the preparation of the compound of example 2, but using 2-(5-bromo-1H-indol-3-yl)acetic acid in step 19 (A) and (3-chloro-4-(4-methylpiperazin-1-yl)phenyl)methanamine (preparation F) in step 19 (B), the title compound was prepared. MS (ESI) (M+H)+=517.02/518.98 1H-NMR (500 MHz, CD3OD) δ 7.73 (s, 1 H), 7.45 (s, 1 H), 7.27-7.38 (m, 3 H), 7.17-7.26 (m, 2 H), 4.49 (s, 2 H), 3.93 (s, 2 H), 3.57-3.68 (m, 2 H), 3.47-3.58 (m, 2 H), 3.28-3.40 (m, 2 H), 3.06-3.18 (m, 2 H), 2.96-3.01 (s, 3 H).

Provenance & Evidence