HCID 57887237, compound → HCID 16114600, compound

HRID 1819709Notes

Reaction equation

HRID 1819709 reaction equation
BrC1C=C2C(C(CC([N:14]=[C:15]([NH2:30])[NH:16][CH2:17][C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:20]([Cl:29])[CH:19]=3)=O)=CN2)=CC=1.[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][C:36]([C:41](=[O:47])[NH:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[C:35]2[CH2:48][C:49]([OH:51])=O>>[C:43]([NH:42][C:41]([C:36]1[NH:37][C:38]2[C:34]([C:35]=1[CH2:48][C:49]([NH:30][C:15]([NH2:14])=[N:16][CH2:17][C:18]1[CH:19]=[C:20]([Cl:29])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:22]([Cl:24])[CH:23]=1)=[O:51])=[CH:33][C:32]([Br:31])=[CH:40][CH:39]=2)=[O:47])([CH3:44])([CH3:46])[CH3:45]

Participants

3

Reactant 2

HCID 57887237HCID 57887237, compoundHCID 178474305HCID 178474305, compound

Product 1

HCID 16114600HCID 16114600, compound

Procedure

In a manner similar to that used in the preparation of the compound of example 1, but using 2-(5-bromo-2-(tert-butylcarbamoyl)-1H-indol-3-yl)acetic acid (preparation I) in step 24 (A), the title compound was prepared. 1H-NMR (500 MHz, CD3OD) δ ppm 1.51 (s, 9 H) 2.20 (s, 3 H) 4.13 (s, 2 H) 4.54 (s, 2 H) 7.37 (m, 4 H) 7.84 (s, 1 H).

Sources & evidence

ORD record
ord-c21001623b0b4fe988a234b7b5ab80e1
Source dataset
uspto-grants-2009_10
Patent number
US07601751B2

Reaction notes

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