HRID1819709

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)NC(=O)c1[nH]c2ccc(Br)cc2c1CC(=O)O

HCID57887237

未命名化合物

结构：CC(=O)Nc1c(Cl)cc(CNC(N)=NC(=O)Cc2c[nH]c3cc(Br)ccc23)cc1Cl

HCID178474305

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1c(Cl)cc(CN=C(N)NC(=O)Cc2c(C(=O)NC(C)(C)C)[nH]c3ccc(Br)cc23)cc1Cl

HCID16114600

未命名化合物

PROCEDURE

实验过程

In a manner similar to that used in the preparation of the compound of example 1, but using 2-(5-bromo-2-(tert-butylcarbamoyl)-1H-indol-3-yl)acetic acid (preparation I) in step 24 (A), the title compound was prepared. 1H-NMR (500 MHz, CD3OD) δ ppm 1.51 (s, 9 H) 2.20 (s, 3 H) 4.13 (s, 2 H) 4.54 (s, 2 H) 7.37 (m, 4 H) 7.84 (s, 1 H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c21001623b0b4fe988a234b7b5ab80e1
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07601751B2
来源说明: uspto-grants-2009_10

反应 SMILES

BrC1C=C2C(C(CC([N:14]=[C:15]([NH2:30])[NH:16][CH2:17][C:18]3[CH:23]=[C:22]([Cl:24])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:20]([Cl:29])[CH:19]=3)=O)=CN2)=CC=1.[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][C:36]([C:41](=[O:47])[NH:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[C:35]2[CH2:48][C:49]([OH:51])=O>>[C:43]([NH:42][C:41]([C:36]1[NH:37][C:38]2[C:34]([C:35]=1[CH2:48][C:49]([NH:30][C:15]([NH2:14])=[N:16][CH2:17][C:18]1[CH:19]=[C:20]([Cl:29])[C:21]([NH:25][C:26](=[O:28])[CH3:27])=[C:22]([Cl:24])[CH:23]=1)=[O:51])=[CH:33][C:32]([Br:31])=[CH:40][CH:39]=2)=[O:47])([CH3:44])([CH3:46])[CH3:45]