Ethanol → Orotic acid, monosodium salt

HRID 1819713Notes

Reaction equation

HRID 1819713 reaction equation
[C:1]([OH:11])(=[O:10])[C:2]1[NH:9][C:7](=[O:8])[NH:6][C:4](=[O:5])[CH:3]=1.[OH-].[Na+:13].CCO>O>[C:1]([O-:11])(=[O:10])[C:2]1[NH:9][C:7](=[O:8])[NH:6][C:4](=[O:5])[CH:3]=1.[Na+:13]

Participants

5

Reactant 3

HCID 702EthanolHCID 967Orotic AcidHCID 14798Sodium Hydroxide

Product 1

HCID 23683036Orotic acid, monosodium salt

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

FIG. 2 illustrates the synthesis of Sodium Methotrexate Orotate. Orotic acid (1.74 g) was treated with sodium hydroxide (0.45 g) in water (100 mL). The mixture was warmed, stirred for 1 h and stored in the refrigerator overnight. Etanol (30 mL) was added to the solution and the precipitate was collected by filtration to give sodium orotate as a colorless solid which was dried in vacuum over night and used for the next step (1.51 g).

Workup

  1. temperatureThe mixture was warmed
  2. customstored in the refrigerator overnight
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-98fb44b0ddfc4c75b65d7aa33f16be3c
Source dataset
uspto-grants-2009_10
Patent number
US07601834B2

Reaction notes

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