Benzo(d)thiazol-2-amine → 2-Furan-2-yl-imidazo[2,1-b]benzothiazole hydrobromide salt

HRID 1819736Notes

Reaction equation

HRID 1819736 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[O:6][CH:7]=[CH:8][CH:9]=1)=O.[NH2:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>>[BrH:1].[O:6]1[CH:7]=[CH:8][CH:9]=[C:5]1[C:3]1[N:10]=[C:11]2[N:15]([CH:2]=1)[C:14]1[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=1[S:12]2

Participants

3

Reactant 2

HCID 8706Benzo(d)thiazol-2-amineHCID 27950762-Bromo-1-(furan-2-yl)ethan-1-one

Product 1

HCID 688206922-Furan-2-yl-imidazo[2,1-b]benzothiazole hydrobromide saltYield 30%

Procedure

The title compound is prepared from 2-Bromo-1-furan-2-yl-ethanone and 2-aminobenzothiazole using method B in 30% yield: mp>250° C. (dec); 1H-NMR (DMSO-d6) 6.63 (s, 1H), 6.78 (s, 1H), 7.48 (t, 1H), 7.60 (t, 1H), 7.77 (s, 1H), 8.09 (d, 1H), 8.13 (d, 1H), 8.68 (s, 1H); Anal. (C13H9BrN2OS ⅔ H2O) C, H, N.

Sources & evidence

ORD record
ord-1dae25da536a4cc4a36c5536ce30da00
Source dataset
uspto-grants-2009_10
Patent number
US07601846B2

Reaction notes

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