Ethyl bromoacetate → HCID 9944960, compound

Participants

Reaction Steps

A mixture of 2-amino-4,5,6,7-tetrahydrobenzothiazole (2.296 g, 14.9 mmol) and ethyl bromoacetate (2.747 g, 16.4 mmol) was refluxed in ethanol (50 mL) containing 3 drops of Et3N for 90 minutes. The reaction mixture was concentrated to half volume in vacuo and the resulting precipitate was filtered and rinsed with cold ethanol, then ether to give a white powder in 79% yield: mp 222-224° C.; 1H-NMR (DMSO-d6) 1.25 (t, 3H), 1.74 (d, 4H), 2.39 (s, 2H), 2.52 (m, 2H), 4.22 (q, 2H), 4.95 (s, 2H), 9.67 (s, 2H); Anal. C11H17Br1N2O2S (C, H, N); HR-MS (EI) m/z 240.0931 (M+).

Provenance & Evidence