HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 10145617, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Mafenide Hydrochloride | HCID 67313 | — |
| Reactant | 5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, ethyl ester | HCID 67656 | — |
| Reactant | Ethyl 2-amino-4-methylthiazole-5-carboxylate | HCID 343747 | — |
| Reactant | 4-Methylsulfonylbenzylamine hydrochloride | HCID 2729269 | — |
| Reactant | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 10145617 | HCID 10145617 | — |
Reaction Steps
A14 was prepared in an manner analogous to example A1 with the exception that in step A1.1 4-aminosulfonylbenzylamine hydrochloride was substituted for 4-methylsulfonylbenzylamine hydrochloride, and in step A1.2 ethyl 2-amino-4-trifluoromethyl-5-thiazole carboxylate was substituted for ethyl 2-amino-4-methyl-5-thiazole carboxylate. LCMS=Ret. Time=1.61 min*, M+=613.20 *HPLC conditions used to determine retention times; 2 min gradient 0-100% B in A (A; 0.1% TFA in 90/10 water/methanol; B; 0.1% TFA in 10/90 water/methanol) using a TMC turbopack column at 220 nm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601836B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-b38b0e798fd549c4b79f647be43bf3d8 |
| Source note | uspto-grants-2009_10 |