Acetic Anhydride → HCID 24899447, compound

HRID 1819858Notes

Reaction equation

HRID 1819858 reaction equation
[CH2:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH2:4][CH2:3][CH:2]1[NH2:14].[C:15](OC(=O)C)(=[O:17])[CH3:16]>N1C=CC=CC=1>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:14][C:15](=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 21221605HCID 21221605, compound

Product 1

HCID 24899447HCID 24899447, compoundYield 48.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following the procedure of Example 1, tetrahydro-dibenzofuran-2-ylamine (0.94 g, 5.0 mmol) and acetic anhydride (0.52 mL, 5.5 mmol) in pyridine (14 mL) provided N-(6,7,8,9-Tetrahydro-dibenzofuran-2-yl)-acetamide (0.56 g). Mp 195.5-197.5° C.; MS m/z 230 ([M+H]+); Anal. Calcd. for C15H17NO2: C, 73.34; H, 6.59; N, 6.11; Found: C, 73.45; H, 6.54; N, 6.06.

Sources & evidence

ORD record
ord-da1998df240a4992872d40a5d2de3052
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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