3,3-Dimethylbutanoyl chloride → N-(2,3-dihydro-1 H-cyclopenta[b]benzofuran-7-yl)-3,3-dimethyl-butyramide

Participants

Reaction Steps

Following the procedure of Example 1, 2,3-dihydro-1H-cyclopenta[b]benzofuran-7-ylamine (0.87 g, 5.0 mmol) and t-butylacetyl chloride (0.77 mL, 5.5 mmol) in pyridine (10 mL) provided N-(2,3-dihydro-1 H-cyclopenta[b]benzofuran-7-yl)-3,3-dimethyl-butyramide (0.82 g). Mp 195.5-197.0 ° c; MS (El) m/z 272 ([M+H]+); Anal. Calcd. for C17H21NO2: C, 75.25; H, 7.80; N, 5.16; Found: C, 75.34; H, 7.82; N, 5.14.

Provenance & Evidence