Pivaloyl chloride → N-(2,3-dihydro-1H-cyclopenta(b)benzofuran-7-yl)-2,2-dimethyl-propionamide

Participants

Reaction Steps

Following the procedure of Example 1, 2,3-dihydro-1H-cyclopenta[b]benzofuran-7-ylamine (0.69 g, 4.0 mmol) and trimethylacetyl chloride (0.55 mL, 4.4 mmol) in pyridine (10 mL) provided N-(2,3-dihydro-1H-cyclopenta(b)benzofuran-7-yl)-2,2-dimethyl-propionamide (0.64 g). Mp 188.5-190.0° C.; MS m/z 258 ([M+H]+); Anal. Calcd. for C16H19NO2: C, 74.68; H, 7.44; N, 5.44; Found: C, 74.67; H, 7.43; N, 5.39.

Provenance & Evidence