HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isovaleryl chloride → N-(2,3-Dihydro-1 H-cyclopenta[b]benzofuran-7-yl)-3-methyl-butyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isovaleryl chloride | HCID 66054 | — |
| Reactant | 2,3-dihydro-1H-cyclopenta[b]benzofuran-7-ylamine | HCID 19621392 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(2,3-Dihydro-1 H-cyclopenta[b]benzofuran-7-yl)-3-methyl-butyramide | HCID 24899953 | 65.1% |
Reaction Steps
Following the procedure of Example 1, 2,3-dihydro-1H-cyclopenta[b]benzofuran-7-ylamine (0.69 g, 4.0 mmol) and isovaleryl chloride (0.55 mL, 4.4 mmol) in pyridine (10 mL) provided N-(2,3-Dihydro-1 H-cyclopenta[b]benzofuran-7-yl)-3-methyl-butyramide (0.67 g). Mp 162.0-163.0° C.; Anal. Calcd. for C16H19NO2: C, 74.68; H, 7.44; N, 5.44; Found: C, 74.67; H, 7.70; N, 5.39.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601856B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-03ea29ce10924dc08e05a997d3fe87b3 |
| Source note | uspto-grants-2009_10 |