Pivaloyl chloride → HCID 24899191, compound

Participants

Reaction Steps

Following the procedure of Example 1, 7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine (1.0 g, 5.0 mmol) and trimethylacetyl chloride (0.68 mL, 5.5 mmol) in pyridine (10 mL) provided 2,2-dimethyl-N-(6,7,8,9-tetrahydro-5H-10-oxa-benzo[a]azulen-3-yl)-propionamide (1.2 g). Mp 208-209° C.; Anal. Calcd. for C18H23NO2: C, 75.76; H, 8.12; N, 4.91; Found: C, 76.06; H, 8.03; N, 4.94.

Provenance & Evidence