Morpholine → HCID 24900204, compound

Participants

Reaction Steps

A mixture of 2-chloro-N-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylacetamide (0.13 g, 0.45 mmol), morpholine (0.049 mL, 0.56 mmol), and cesium carbonate (0.29 g, 0.90 mmol) in acetonitrile (5 mL) was stirred overnight at room temperature. The reaction mixture was concentrated and the crude material was purified using reverse-phase HPLC to provide 2-morpholin-4-yl-N-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylacetamide (0.085 g). MS (ESI) m/z 329 ([M+H]+).

Provenance & Evidence