HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N1-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylglycinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 24896738 | HCID 24896738 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N1-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylglycinamide | HCID 24896739 | 72.2% |
Reaction Steps
A solution of tert-butyl [2-oxo-2-(7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylamino)ethyl]carbamate (0.10 g) in 1:1 trifluoroacetic acid:dichloromethane (5 mL) was stirred at room temperature for 30 min and then concentrated to provide N1-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-ylglycinamide (52 mg) as its trifluoroacetic acid salt. MS (ESI) m/z 259 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601856B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-0a391e0b22c14790886a386d4441992b |
| Source note | uspto-grants-2009_10 |