HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57890297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-Methyl-L-proline | HCID 643474 | — |
| Reactant | 7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine | HCID 12884883 | — |
| Product | HCID 57890297 | HCID 57890297 | 69.4% |
Reaction Steps
Following the procedure of Example 30, triethylamine (0.21 mL, 1.5 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (0.24 g, 1.3 mmol), N-hydroxybenzotriazole (0.17 g, 1.3 mmol), N-methyl-L-proline (0.077 g, 0.60 mmol), and 7,8,9,10-tetrahydro-6H-benzo[b]-cyclohepta[d]furan-2-ylamine (0.12 g, 0.60 mmol) provided 1-methyl-N-7,8,9,10-tetrahydro-6H-benzo[b]cyclohepta[d]furan-2-yl-L-prolinamide (0.13 g). MS (ES) m/z 313.2 ([M+H]+); HRMS: calcd for C19H24N2O2+H+, 313.19105; found (ESI, [M+H]+), 313.1918.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601856B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-387506a09ff5472b9f17bbee42321910 |
| Source note | uspto-grants-2009_10 |