3,5,5-Trimethylhexanoyl chloride → HCID 24898081, compound

HRID 1819902Notes

Reaction equation

HRID 1819902 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[CH3:17][CH:18]([CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:19][C:20](Cl)=[O:21]>ClC(Cl)C>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:20](=[O:21])[CH2:19][CH:18]([CH3:17])[CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 1619293,5,5-Trimethylhexanoyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24898081HCID 24898081, compoundYield 100.5%

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.15 g, 0.70 mmol), 3,5,5-trimethylhexanoyl chloride (0.14 mL, 0.73 mmol), and poly(vinylpyridine) (0.5 g) in dichloroethane (15 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)-3,5,5-trimethylhexanamide (0.25 g). MS (ESI) m/z 356 ([M+H]+).

Sources & evidence

ORD record
ord-aee01e9e4cf2429db0c8742b33f00b0e
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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