2-Thiophenecarbonyl chloride → HCID 24897432, compound

HRID 1819903Notes

Reaction equation

HRID 1819903 reaction equation
[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH2:16].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22](Cl)=[O:23]>ClCCl>[CH:1]1[C:9]2[C:8]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[NH:16][C:22]([C:18]1[S:17][CH:21]=[CH:20][CH:19]=1)=[O:23]

Participants

4

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 57890287HCID 57890287, compound

Product 1

HCID 24897432HCID 24897432, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure of Example 1, 6,7,8,9,10,11-Hexahydro-benzo[b]-cycloocta[d]furan-2-ylamine (0.15 g, 0.70 mmol), 2-thiophenecarbonyl chloride (0.082 mL, 0.77 mmol), and poly(vinylpyridine) (0.5 g) in dichloromethane (17 mL) provided N-(6,7,8,9,10,11-hexahydrobenzo[b]cycloocta[d]furan-2-yl)thiophene-2-carboxamide (0.098 g). MS (ESI) m/z 326 ([M+H]+).

Sources & evidence

ORD record
ord-341ec1817c844986ac5dc9749e9a58fd
Source dataset
uspto-grants-2009_10
Patent number
US07601856B2

Reaction notes

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