HCID 10025041, compound → HCID 11756332, compound

HRID 1819933Notes

Reaction equation

HRID 1819933 reaction equation
[CH2:1]([C:3]([C:21]1[S:25][C:24]([C:26](O)=[O:27])=[C:23]([CH3:29])[CH:22]=1)([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]([OH:19])[C:15]([CH3:18])([CH3:17])[CH3:16])=[C:8]([CH3:20])[CH:7]=1)[CH2:4][CH3:5])[CH3:2].Cl.[CH3:31][O:32][C:33](=[O:38])[C:34]([NH2:37])([CH3:36])[CH3:35]>>[CH3:31][O:32][C:33](=[O:38])[C:34]([NH:37][C:26]([C:24]1[S:25][C:21]([C:3]([CH2:4][CH3:5])([C:6]2[CH:11]=[CH:10][C:9]([O:12][CH2:13][CH:14]([OH:19])[C:15]([CH3:18])([CH3:17])[CH3:16])=[C:8]([CH3:20])[CH:7]=2)[CH2:1][CH3:2])=[CH:22][C:23]=1[CH3:29])=[O:27])([CH3:36])[CH3:35]

Participants

3

Reactant 2

HCID 10025041HCID 10025041, compoundHCID 13258034Methyl 2-aminoisobutyrate hydrochloride

Product 1

HCID 11756332HCID 11756332, compoundYield 71.4%

Procedure

Using the procedure analogous to Example 52, enantiomer 2 of 5-{1-Ethyl-1-[4-(2-hydroxy-3,3-dimethyl-butoxy)-3-methyl-phenyl]-propyl}-3-methyl-thiophene-2-carboxylic acid (Example 8) (0.5 g, 1.19 mmol) and 2-amino-2-methyl-propionic acid methyl ester hydrochloride salt (0.2 g, 1.31 mmol) to give the title compound (0.44 g, 0.85 mmol, 71%). 1H NMR and LC/MS: identical to (enantiomer-1), Example 70.

Sources & evidence

ORD record
ord-2275dfd251fe456f98eac929610dd834
Source dataset
uspto-grants-2009_10
Patent number
US07601850B2

Reaction notes

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