HCID 68625913, compound → HCID 68626638, compound

HRID 1819946Notes

Reaction equation

HRID 1819946 reaction equation
C([O:5][C:6](=[O:8])[CH3:7])(C)(C)C.[CH3:9][C:10]([CH3:38])([CH3:37])[C:11](=[O:36])[CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([C:25]2[S:29][C:28]([S:30]([NH2:33])(=[O:32])=[O:31])=[C:27]([CH3:34])[CH:26]=2)([CH2:23][CH3:24])[CH2:21][CH3:22])=[CH:16][C:15]=1[CH3:35]>Cl.O1CCOCC1>[C:6]([OH:8])(=[O:5])[CH3:7].[CH3:38][C:10]([CH3:9])([CH3:37])[C:11](=[O:36])[CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([C:25]2[S:29][C:28]([S:30]([NH2:33])(=[O:32])=[O:31])=[C:27]([CH3:34])[CH:26]=2)([CH2:21][CH3:22])[CH2:23][CH3:24])=[CH:16][C:15]=1[CH3:35]

Participants

3

Reactant 1

HCID 68625913HCID 68625913, compound

Product 1

HCID 68626638HCID 68626638, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A solution of (5-{1-[4-(3,3-dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-thiophene-2-sulfonylamine)-acetic acid tert-butyl ester (320 mg, 0.57 mmol) in 4N HCl/dioxane (10 ml) is stirred at RT overnight. The reaction is concentrated and chromatographed (Hex to 0.5% AcOH in 50% EtOAc/Hex) to give the title compound (250 mg, 87%).

Workup

  1. concentrationThe reaction is concentrated
  2. customchromatographed (Hex to 0.5% AcOH in 50% EtOAc/Hex)

Sources & evidence

ORD record
ord-4dbce45eb6094ff28fe692c08da48060
Source dataset
uspto-grants-2009_10
Patent number
US07601850B2

Reaction notes

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