Tetrabutylammonium Fluoride → HCID 86605563, compound

Participants

Reaction Steps

To a 0° C. solution of 5-{1-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-phenyl]-1-ethyl-propyl}-3-methyl-thiophene-2-sulfonic acid dimethylaminemethyleneamide (6.1 g, 11.68 mmol) in THF (150 ml) is added dropwise tetrabutylammonium fluoride (15.62 ml, 15.62 mmol, 1.0 M in THF) and is warmed to RT for 1 h. The reaction is quenched with satd aqueous NH4Cl (100 ml) and extracted with Et2O (2×200 ml). The combined organic layers are dried MgSO4 dried, concentrated and chromatographed (120 g SiO2, 50% EtOAc/Hex) to yield the title compound (4.63 g, 97%).

Provenance & Evidence