Sodium borohydride → HCID 57890118, compound

HRID 1819962Notes

Reaction equation

[CH2:1]([C:3]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])=[C:14]([CH3:26])[CH:13]=1)([C:6]1[S:7][CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:4][CH3:5])[CH3:2].[BH4-].[Na+]>>[CH2:1]([C:3]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH:20]([OH:25])[C:21]([CH3:24])([CH3:23])[CH3:22])=[C:14]([CH3:26])[CH:13]=1)([C:6]1[S:7][CH:8]=[C:9]([CH3:11])[CH:10]=1)[CH2:4][CH3:5])[CH3:2]

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 57890134HCID 57890134, compound

Product 1

HCID 57890118HCID 57890118, compound

Procedure

Using a procedure analogous to Example 134B, 1-{4-[1-ethyl-1-(4-methyl-thiophen-2-yl)-propyl]-2-methyl-phenyl}-4,4-dimethyl-pentan-3-one and NaBH4 give the title compound (quant).

Sources & evidence

ORD record: ord-3bd294d6f3664340af5f06e8fddc7889
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07601850B2

Reaction notes

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