HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1820105Generated: October 28, 2026
Diethylamine → 5-Bromo-2-diethylamino-nicotinic acid
https://huagongshe.com/reaction/1820105
Participants
| Role | Name | HCID | Charge |
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| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | 5-Bromo-2-fluoropyridine-3-carboxylic acid | HCID 24721371 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-Bromo-2-diethylamino-nicotinic acid | HCID 59700072 | — |
Reaction Steps
880 mg (4.00 mmol) of 5-bromo-2-fluoronicotinic acid was dissolved in 3 ml of acetonitrile. 1.0 ml (9.7 mmol) of diethylamine was added and the resulting mixture heated to 80° C. for 18 h. The mixture was evaporated and the resulting brown oil used without further purification. MS: m/z 273 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07601839B2 |
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| Source dataset | uspto-grants-2009_10 |
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| ORD ID | ord-ac50e990baff45168542c2c1e6022d9a |
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| Source note | uspto-grants-2009_10 |
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