関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | N-(2,6-dimethyl-4-nitrophenyl)acetamide | HCID 50851089 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,6-Dimethyl-4-nitroaniline | HCID 28159 | 97.5% |
反応手順
Concentrated hydrochloric acid (17.5 mL) was added to N-(2,6-dimethyl-4-nitro-phenyl)-acetamide (5.05 g) and heated to 140° C. for 30 minutes in a sealed microwave process vial. The reaction mixture was neutralized with solid sodium carbonate in water and the precipitated product was collected by filtration and washed with water (100 mL) to furnish 3.93 g (97% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSO-d6): 2.15 (s, 6H), 6.15 (b, 2H), 7.79 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07601870B2 |
|---|
| 出典データセット | uspto-grants-2009_10 |
|---|
| ORD ID | ord-6495e0fce7c44ab6b87b955008f683f2 |
|---|
| 出典メモ | uspto-grants-2009_10 |
|---|
