4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 57889880, compound

HRID 1820175Notes

Reaction equation

HRID 1820175 reaction equation
[C:1](C(N)(CCC)C(O)=O)(=O)C1C=CC=CC=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2([OH:30])[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:20][CH:19]=1.[C:31]([NH:39][CH:40]([C:44]([OH:46])=O)[CH:41]([CH3:43])C)(=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.Cl.ClC1C=CC(C2CCNCC2)=CC=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2([OH:30])[CH2:25][CH2:26][N:27]([C:44](=[O:46])[CH:40]([NH:39][C:31](=[O:38])[C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[CH2:41][CH2:43][CH3:1])[CH2:28][CH2:29]2)=[CH:20][CH:19]=1

Participants

5

Reactant 4

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 2266823-Methyl-2-(phenylformamido)butanoic acidHCID 27578434-(4-chlorophenyl)piperidine HydrochlorideHCID 67299648HCID 67299648, compound

Product 1

HCID 57889880HCID 57889880, compound

Procedure

Example 216 was prepared in a similar manner as described for the preparation of Example 208 with the exceptions that benzoyl-2-aminopentanoic acid and 4-(4-chlorophenyl)-4-hydroxypiperidine were substituted for benzoyl-DL-valine and 4-(4-chlorophenyl)piperidine hydrochloride, respectively. MS found: (M+H)+=415.

Workup

  1. customExample 216 was prepared in a similar manner

Sources & evidence

ORD record
ord-4d58f233e4f842a8afb7ac9e7326ac41
Source dataset
uspto-grants-2009_10
Patent number
US07601844B2

Reaction notes

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