4-(4-Chlorophenyl)-4-hydroxypiperidine → HCID 57889278, compound

HRID 1820177Notes

Reaction equation

HRID 1820177 reaction equation
[C:1](C(N)(CCCC)C(O)=O)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2([OH:33])[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1.[C:34](NC(C(O)=O)C(C)C)(=[O:41])[C:35]1C=[CH:39][CH:38]=[CH:37][CH:36]=1.Cl.ClC1C=CC(C2CC[NH:61]CC2)=CC=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2([OH:33])[CH2:28][CH2:29][N:30]([C:34](=[O:41])[CH:35]([NH:61][C:1](=[O:2])[O:3][CH2:4][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:36][CH2:37][CH2:38][CH3:39])[CH2:31][CH2:32]2)=[CH:23][CH:22]=1

Participants

5

Reactant 4

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 2266823-Methyl-2-(phenylformamido)butanoic acidHCID 27578434-(4-chlorophenyl)piperidine HydrochlorideHCID 17811277HCID 17811277, compound

Product 1

HCID 57889278HCID 57889278, compound

Procedure

Example 218 was prepared in a similar manner as described for the preparation of Example 208 with the exceptions that Cbz-2-aminohexanoic acid and 4-(4-chlorophenyl)-4-hydroxypiperidine were substituted for benzoyl-DL-valine and 4-(4-chlorophenyl)piperidine hydrochloride, respectively. MS found: (M+H)+=460.

Workup

  1. customExample 218 was prepared in a similar manner

Sources & evidence

ORD record
ord-8859ca05bf974756a2016b84e33c66d4
Source dataset
uspto-grants-2009_10
Patent number
US07601844B2

Reaction notes

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