(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acid → HCID 57888965, compound

HRID 1820248Notes

Reaction equation

HRID 1820248 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][C:9]2([CH3:15])[CH3:14])=[CH:4][CH:3]=1.[NH:16]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@@H:17]([C:21](O)=[O:22])[CH:18]([CH3:20])[CH3:19]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([C:21](=[O:22])[C@H:17]([NH:16][C:24](=[O:25])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH:18]([CH3:20])[CH3:19])[CH2:10][C:9]2([CH3:15])[CH3:14])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 637605(2R)-2-(((tert-butoxy)carbonyl)amino)-3-methylbutanoic acidHCID 57725142HCID 57725142, compound

Product 1

HCID 57888965HCID 57888965, compound

Procedure

The title compound was prepared from 4-(4-fluorophenyl)-3,3-dimethylpiperidine and Boc-D-Val-OH using the procedure described in Example 581, Step 5. MS (ESI+)=351.40, (M-tert-Bu)+.

Sources & evidence

ORD record
ord-ec7e4a68391c4613ad6b48d08fe990f5
Source dataset
uspto-grants-2009_10
Patent number
US07601844B2

Reaction notes

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