HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentanecarbonyl chloride → HCID 57889090, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentanecarbonyl chloride | HCID 78284 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-1-oxobutan-2-aminium chloride | HCID 86614930 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57889090 | HCID 57889090 | 52.3% |
Reaction Steps
(R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-1-oxobutan-2-aminium chloride (52.4 mg, 0.14 mmol), cyclopentane carbonylchloride (20 mg, 0.17 mmol), THF (5 mL), and DIPEA (135 mg, 1.1 mmol) were stirred overnight at rt. The reaction was concentrated, and Example 627 was isolated as a white solid using preparative reverse-phase HPLC (30.75 mg, 52.3% yield), M+H=421.31.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601844B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-a22b87f69e224318af19a360cd6c0819 |
| Source note | uspto-grants-2009_10 |