HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(chlorocarbonyl)benzoate → HCID 57889218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(chlorocarbonyl)benzoate | HCID 15563901 | — |
| Reactant | (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-1-oxobutan-2-aminium chloride | HCID 86614930 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 57889218 | HCID 57889218 | — |
Reaction Steps
(R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-1-oxobutan-2-aminium chloride (52.4 mg, 0.14 mmol), methyl 3-(chlorocarbonyl)benzoate (33 mg, 0.17 mmol), THF (5 mL), and diispropylethylamine (135 mg, 1.1 mmol) were stirred overnight at rt. The reaction was concentrated and the product isolated as a white solid using preparative reverse-phase HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601844B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-9b1813248e264bd097578976d1817765 |
| Source note | uspto-grants-2009_10 |