Ethanol → HCID 23109916, compound

Participants

Reaction Steps

After dissolving N-[1-[2-[1-[2-(1-oxo-2-isoindolinyl)ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide (167 mg, 0.30 mmol) in ethyl acetate:ethanol=1:1 (4 mL), a 4N hydrochloric acid/ethyl acetate solution (0.25 mL, 1.00 mmol) was added. The reaction mixture was stirred at room temperature for 5 minutes and then concentrated under reduced pressure. The obtained residue was dissolved in ethanol (10 mL) and the solution was concentrated under reduced pressure to about 0.5 mL, after which 2-propanol (10 mL) was added and the mixture was concentrated under reduced pressure to obtain the title compound as a light brown amorphous substance (124 mg, 0.21 mmol) (70% yield).

Provenance & Evidence