Ethanol → N-[1-[2-[1-[2-(Morpholino)ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide dihydrochloride

Participants

Reaction Steps

After adding a 4N hydrochloric acid/ethyl acetate solution (0.5 mL, 2.0 mmol) to a solution of N-[1-[2-[1-[2-(morpholino)ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide (283 mg, 0.56 mmol) in ethyl acetate (4 mL), the mixture was stirred at room temperature for 10 minutes (producing a white precipitate). Ethanol (0.5 mL) was added to the reaction mixture (to dissolve the precipitate), and the solution was concentrated under reduced pressure to obtain the title compound as a white amorphous solid (283 mg) (87% yield).

Provenance & Evidence