1-Cyclohexylpiperazine → HCID 68683942, compound

HRID 1820375Notes

Reaction equation

HRID 1820375 reaction equation
[N:1]1([C:7]([C:9]2[N:10]([CH2:21][C:22]([F:25])([F:24])[F:23])[C:11]3[C:16]([CH:17]=2)=[CH:15][C:14]([C:18](O)=[O:19])=[CH:13][CH:12]=3)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:26]1([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:26]1([N:32]2[CH2:37][CH2:36][N:35]([C:18]([C:14]3[CH:15]=[C:16]4[C:11](=[CH:12][CH:13]=3)[N:10]([CH2:21][C:22]([F:24])([F:23])[F:25])[C:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])=[CH:17]4)=[O:19])[CH2:34][CH2:33]2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 872981-CyclohexylpiperazineHCID 686815812-(Morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid

Product 1

HCID 68683942HCID 68683942, compoundYield 65%

Procedure

The title compound was synthesized in analogy to example 46, intermediate e), from 2-(morpholine-4-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indole-5-carboxylic acid and 1-cyclohexylpiperazine (commercially available), to give the desired product as a white solid (65%).

Sources & evidence

ORD record
ord-a5257152a19f4485ba24b1ca8a4937bd
Source dataset
uspto-grants-2009_10
Patent number
US07601711B2

Reaction notes

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