HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylethanol, (S)- → HCID 68681142, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylethanol, (S)- | HCID 443135 | — |
| Reactant | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Reactant | (Cyanomethyl)trimethylphosphonium chloride | HCID 57431663 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68680853 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 68681142 | HCID 68681142 | 32% |
Reaction Steps
Example 123 was independently synthesized according to example 74 under inversion of the configuration (e.e. >94%), from (cyanomethyl)trimethylphosphonium chloride (prepared according to Tetrahedron Lett. 1996, 37 (14), 2459-62), potassium bis(trimethylsilyl)amide, (S)-1-phenylethanol and (4,4-difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 32) in toluene, to give the compound as a light brown foam (32%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-db782720fd0246bf8a07594e99388b73 |
| Source note | uspto-grants-2009_10 |