HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropane → [5-(4-Cyclobutyl-piperazine-1-carbonyl)-1-isopropyl-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | [5-(4-Cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 68683577 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [5-(4-Cyclobutyl-piperazine-1-carbonyl)-1-isopropyl-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone | HCID 24757073 | 34% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [5-(4-cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4,4-difluoro-piperidin-1-yl)-methanone (example 41), sodium hydride and 2-bromopropane in N,N-dimethylformamide, to give the desired product as a colorless foam (34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-0052dfb88e024f6f864164cee3e2e7fe |
| Source note | uspto-grants-2009_10 |