HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68681657, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2,2-Trifluoroethyl Methanesulfonate | HCID 556565 | — |
| Reactant | HCID 68680808 | HCID 68680808 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68681657 | HCID 68681657 | 73% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from (RS)-(4,4-difluoro-piperidin-1-yl)-[5-(3-dimethylamino-pyrrolidine-1-carbonyl)-1H-indol-2-yl]-methanone (example 42, intermediate a)), sodium hydride and 2,2,2-trifluoroethyl methanesulfonate in N,N-dimethylformamide, to give the desired product as a colorless foam (73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-3bf39d8825b8439e84fe4888a8ee3d4d |
| Source note | uspto-grants-2009_10 |