HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenyl-2-propanol → (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1-(1-methyl-1-phenyl-ethyl)-1H-indol-2-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenyl-2-propanol | HCID 12053 | — |
| Reactant | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| Reactant | (Cyanomethyl)trimethylphosphonium chloride | HCID 57431663 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68680853 | — |
| Product | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1-(1-methyl-1-phenyl-ethyl)-1H-indol-2-yl]-methanone | HCID 68681432 | 9% |
Reaction Steps
The title compound was synthesized in analogy to example 74, from (cyanomethyl)trimethylphosphonium chloride (prepared according to Tetrahedron Lett. 1996, 37 (14), 2459-62), potassium bis(trimethylsilyl)amide, 2-phenyl-2-propanol and (4,4-difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 32), to give the desired product as a yellow foam (9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-7966e79b5e534798afae57e695840224 |
| Source note | uspto-grants-2009_10 |