HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68681279, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Reactant | HCID 68680741 | HCID 68680741 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68681279 | HCID 68681279 | 44% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [2-(4,4-difluoro-piperidine-1-carbonyl)-1H-indol-5-yl]-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone (example 44), sodium hydride and (2-bromoethoxy)-tert-butyldimethylsilane (commercially available) in N,N-dimethylformamide, to give the desired product as a colorless oil (44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-c3fe7a53c344466b8c3b6b5a053a52e6 |
| Source note | uspto-grants-2009_10 |