HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68684089, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,2,2-Trifluoroethyl Methanesulfonate | HCID 556565 | — |
| Reactant | HCID 68682832 | HCID 68682832 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68684089 | HCID 68684089 | 56% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [2-(4,4-difluoro-piperidine-1-carbonyl)-1H-indol-5-yl]-(4-morpholin-4-yl-piperidin-1-yl)-methanone (example 170), sodium hydride and 2,2,2-trifluoroethyl methanesulfonate in N,N-dimethylformamide, to give the desired product as a brown oil (56%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-109eb8580483455d919ca1cf2b31a2ee |
| Source note | uspto-grants-2009_10 |