HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68682000, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | HCID 68683127 | HCID 68683127 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68682000 | HCID 68682000 | 80% |
Reaction Steps
The title compound was synthesized in analogy to example 51, from [5-(4-cyclobutyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(1,1-dioxothiomorpholin-4-yl)-methanone (example 202), sodium hydride and cyclopropylmethyl bromide in N,N-dimethylformamide, to give the desired product as a colorless foam (80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-379fa05b1d024da188ce85a16480d4e1 |
| Source note | uspto-grants-2009_10 |