HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 24757074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Chloropyridine-4-boronic acid | HCID 5151595 | — |
| Reactant | (4,4-Difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68680853 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 24757074 | HCID 24757074 | 20% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from (4,4-difluoro-piperidin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 32), 2-chloropyridine-4-boronic acid, copper(II) acetate, pyridine and using chloroforme instead of dichloromethane as solvent, to give the desired product as a light yellow foam (20%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-83a16d54ccaf4bb1ac137929f955dac5 |
| Source note | uspto-grants-2009_10 |