HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 86615822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Chloropyridine-4-boronic acid | HCID 5151595 | — |
| Reactant | HCID 68682972 | HCID 68682972 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 86615822 | HCID 86615822 | 34% |
Reaction Steps
The title compound was synthesized in analogy to example 66, from [4-chloro-2-(4,4-difluoro-piperidine-1-carbonyl)-1H-indol-5-yl]-(4-isopropyl-piperazin-1-yl)-methanone (example 228), 2-chloropyridine-4-boronic acid, copper(II) acetate, pyridine and using chloroforme instead of dichloromethane as solvent, to give the desired product as a colorless foam (34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-fc9684325d9c41cfbe34e1952db38c0d |
| Source note | uspto-grants-2009_10 |