HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isopropylpiperazine → HCID 68682284, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 68680065 | HCID 68680065 | — |
| Reactant | HCID 68681331 | HCID 68681331 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68682284 | HCID 68682284 | — |
Reaction Steps
The title compounds were synthesized in analogy to example 1, from 7-chloro-2-(4,4-difluoro-piperidine-1-carbonyl)-1H-indole-5-carboxylic acid hydrochloride and 7-chloro-1H-indole-2,5-dicarboxylic acid (intermediate c), 1-isopropylpiperazine (commercially available), O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (commercially available) and N,N-diisopropylethylamine in N,N-dimethylformamide. The products were separated by silica gel chromatography using dichloromethane:methanol (19:1 v/v) as eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07601711B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-24c0ad0fc9344be7be0bdbd5494b41f8 |
| Source note | uspto-grants-2009_10 |