HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetonitrile → 4-Cyanomethyl-piperazine-1-carboxylic Acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Cyanomethyl-piperazine-1-carboxylic Acid ethyl ester | HCID 58860509 | — |
Reaction Steps
To a solution of 3 g (19.0 mmol) of ethyl N-piperazinecarboxylate in 25 mL of CH3CN was added 1.57 g (1.32 mL 20.1 mmol) of 2-chloroacetonitrile and 15.6 g (95 mmol) K2CO3.1½H2O. The suspension was stirred at room temperature for 16 hours. The reaction was analyzed using TLC (35% Ethyl acetate/Hexanes, product r.f. 0.38 vs. s.m. r.f. of 0.02). The analysis indicated the reaction was complete. The golden yellow solution was evaporated to dryness. The residue was extracted with CH2Cl2/H2O, dried with MgSO4, and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605143B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-250495473a834bc49fd99047925eb564 |
| Source note | uspto-grants-2009_10 |