HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cortisol → Hydrocortisone 4-bromobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cortisol | HCID 5754 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromobutyryl chloride | HCID 70225 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Hydrocortisone 4-bromobutanoate | HCID 86606384 | — |
Reaction Steps
Five portions of 4-bromobutanoylchloride (0.35 ml×5) and potassium carbonate (0.4 g×5) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5 and stirred for 5 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605151B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-66697b06c9704bf3ac55410a566bc732 |
| Source note | uspto-grants-2009_10 |