HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(5-Nitropyridin-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate | HCID 16217943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(5-Nitropyridin-2-yl)piperazine | HCID 2928799 | 96% |
Reaction Steps
4-(5-Nitropyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester (3.08 g, 10 mmol) was treated with 15% TFA in dichloromethane (50 mL) at 25° C. for 1 h. The solution was concentrated in vacuo to provide 1-(5-nitropyridin-2-yl)piperazine as a brown solid (2.0 g, 96% yield over two steps). MS (ES+) m/z 209.4 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605161B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-09853a070693464e97ba4a0673cdb209 |
| Source note | uspto-grants-2009_10 |