反应详情

温度

-10 °C

Lithium triflate was suspended in CH3CN (15 mL) and the mixture is cooled to −10° C. 2-(Trifluoromethyl)oxirane is added and the suspension is allowed to warm to RT with stirring. Benzylamine (6.33 mL, 58 mmol, Aldrich) is added all-at-once and the resultant solution is stirred for 25 minutes. The reaction is quenched by pouring into CH2Cl2 (200 mL) and washing 3× with H2O (200 mL). The organic layer is dried over Na2SO4 and filtered. The product is purified on a Biotage Flash 75L using 20:70:10 CH2Cl2:pentane:triethylamine as eluent. The product containing fractions are pooled and the solvent is removed by rotary evaporation. The product is dried under vacuum at 100° C. yielding a white crystalline solid.

1. temperatureto warm to RT
2. stirringis stirred for 25 minutes
3. customThe reaction is quenched
4. additionby pouring into CH2Cl2 (200 mL)
5. washwashing 3× with H2O (200 mL)
6. dry with materialThe organic layer is dried over Na2SO4
7. filtrationfiltered
8. customThe product is purified on a Biotage Flash 75L
9. additionThe product containing fractions
10. customthe solvent is removed by rotary evaporation
11. customThe product is dried under vacuum at 100° C.
12. customyielding a white crystalline solid