HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 87964453, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | Isohexane ethyl acetate | HCID 21882781 | — |
| Reactant | HCID 68980759 | HCID 68980759 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 87964453 | HCID 87964453 | — |
Reaction Steps
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.9 g) and 1-hydroxybenzotriazole hydrate (2.0 g) were added to a solution of 2-methoxyphenylamino acetonitrile (2.0 g) and N-tert-butoxycarbonyl L-leucine (2.5 g) in N,N-dimethylformamide (20 ml) at room temperature followed by N,N-diisopropylethylamine (5.3 ml) and stirred at room temperature overnight. The mixture was diluted with water, extracted into ethyl acetate and dried (MgSO4). The solvent was removed under vacuum to leave an oil which was subjected to column chromatography on silica eluting with isohexane/ethyl acetate 2:1 to give a colourless oil (3.7 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605159B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-b3a75a72f11940d8bf4d0e16a04c1316 |
| Source note | uspto-grants-2009_10 |